resveratrol

Overview

Resveratrol is a naturally occurring polyphenolic compound predominantly found in the skin of red grapes, berries, and peanuts. It is recognized for its antioxidant, anti-inflammatory, and potential anticancer properties. Resveratrol exerts its biological effects primarily through modulation of various signaling pathways, including the sirtuin 1 (SIRT1) pathway, which is implicated in cellular stress resistance and longevity. Its ability to activate the SIRT1 pathway links resveratrol to mechanisms of aging and metabolic regulation, making it a subject of interest in the study of age-related diseases and conditions such as type 2 diabetes and cardiovascular diseases.

Focus of Latest Publications

Recent investigations into resveratrol have focused extensively on overcoming its poor aqueous solubility and low oral bioavailability through advanced formulation technologies. Researchers have developed multiple delivery systems including spray-dried inhalable powders, polymeric nanoparticles, liposomes, microneedles, and polymer-based emulsions, each designed to enhance bioavailability and enable targeted tissue distribution. A spray-dried resveratrol formulation for pulmonary delivery achieved a lung-to-plasma area under the curve ratio of 282 compared to 77 for micronized resveratrol, demonstrating superior pulmonary accumulation with excellent tolerability. Hydrophobic resveratrol derivatives showed reduced phase II metabolism and improved permeability across intestinal models, while carrier systems based on selenium nanoparticles, alginate matrices, and mesoporous silica nanoparticles have been engineered to enhance both stability and controlled release.

Recent studies have demonstrated resveratrol's therapeutic potential across multiple disease contexts through distinct mechanistic pathways. In neurological disease models, resveratrol preserved blood–brain barrier integrity and reduced infarct area in stroke by modulating the sFRP4/Wnt signaling pathway and suppressing inflammatory mediators. The cis-isomer of resveratrol inhibited mitochondrial endonuclease G activity and improved motor symptoms in a mouse model of Parkinson's disease, whereas the trans-isomer enhanced endonuclease activity—revealing unexpected opposing effects of resveratrol isomers on EndoG. In a neurogenic bladder model, resveratrol suppressed the AKT/mTOR/S6K signaling pathway, reducing bladder fibrosis, alleviating urothelial pyroptosis, and improving urodynamic function.

Resveratrol has emerged as a potent inducer of ferroptosis in pancreatic cancer models, downregulating ferroptosis suppressors including GPX4 and CTSB while activating the HIF-1 and transforming growth factor-β pathways. In hepatocellular and colorectal cancer contexts, resveratrol-loaded nanocarrier systems achieved enhanced tumor accumulation and cytotoxicity through both direct antiproliferative effects and immune modulation, with resveratrol prodrug nanoparticles triggering immunogenic cell death and activating natural killer and NKT cell responses. For inflammatory and oxidative stress-associated conditions, resveratrol delivered via selenium nanoparticles attenuated silicosis-induced pulmonary inflammation and fibrosis by restoring antioxidant enzyme activity and suppressing NF-κB and transforming growth factor-β-mediated fibrotic signaling. Similarly, intra-articular resveratrol formulations reduced swelling and inflammatory cytokine production in gouty arthritis and osteoarthritis models while preserving cartilage architecture and suppressing macrophage-mediated inflammation.

Recent advances in formulation science have extended resveratrol applications to previously challenging anatomical sites and disease contexts. Three-dimensional-printed microneedles and mucoadhesive nanofibrous systems have enabled intradermal and nasal delivery of resveratrol-loaded nanoparticles for topical oxidative stress and inflammatory disorders, while gelatin-stabilized high internal phase emulsions demonstrated superior thermal and ultraviolet protection with controlled intestinal release kinetics. Cyclodextrin-based polymers enhanced resveratrol encapsulation and intrinsic antioxidant activity for cartilage repair applications, improving human chondrocyte metabolic activity and extracellular matrix deposition. The synthesis of resveratrol dimers through biomimetic radical coupling has generated dihydrobenzofuran-containing scaffolds including δ-viniferin and gnetin C, opening new structural possibilities for therapeutic development.

Key Publications

• NEWJun Design and characterization of a resveratrol spray-dried inhalable formulation for pulmonary delivery with in vivo pharmacokinetic and toxicological evaluation. (Drug delivery, 2026, PMID 42366507): "Resveratrol is a polyphenolic compound with therapeutic potential for pulmonary diseases, yet its use is limited mostly due to low oral bioavailability."
• NEWJun Uptake and predictors of newborn respiratory syncytial virus (RSV) immunisation with nirsevimab in Ireland's national pilot programme: a cross-sectional study. (BMJ open, 2026, PMID 42331576): "To assess uptake of nirsevimab, a long-acting monoclonal antibody for respiratory syncytial virus (RSV) prevention, during the first season of Ireland's Pathfinder pilot universal newborn immunisation programme and to identify socio-demographic and perinatal predictors of uptake."
• NEWJun Resveratrol Alleviates Neurogenic Bladder Fibrosis and Urothelial Pyroptosis by Inhibiting the AKT/mTOR Signaling Pathway. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026, PMID 42319380): "In this study, we established an NB rat model by bilateral L6-S1 spinal nerve transection and evaluated the therapeutic effects of resveratrol."
• NEWJun A rapid, multiplex, one-pot CRISPR/Dx system for visual detection of influenza A, influenza B, and respiratory syncytial viruses. (Analytical methods : advancing methods and applications, 2026, PMID 42299927): "The detection of Influenza A Virus (IAV), Influenza B Virus (IBV), and Respiratory Syncytial Virus (RSV) presents significant diagnostic challenges due to the high similarity of clinical symptoms with other respiratory infections, leading to the need for multiplexed, rapid testing."
• NEWJun Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination. (Proceedings of the National Academy of Sciences of the United States of America, 2026, PMID 42296341): "Accordingly, molecules modulating EndoG activity may have high therapeutic potentials. Searching for compounds affecting paternal mitochondrial elimination (PME) in Caenorhabditis elegans, we have identified resveratrol (RSV), a well-known natural compound, as a PME inhibitor."
• Jun Biomimetic Radical Oligomerization Enables the Total Synthesis of Five Resveratrol Dimers. (Organic letters, 2026, PMID 42247673): "A biomimetic platform for the selective synthesis of dihydrobenzofuran (DHB)-containing resveratrol dimers from differentiated resveratrol monomers is disclosed."
• May Bibliometric analysis of natural medicine in the treatment of Alzheimer's disease: Trends, hotspots, and emerging research fields. (Journal of Alzheimer's disease : JAD, 2026, PMID 42216664): "Promising natural agents include Ginkgo biloba, ginseng, curcumin, resveratrol, and Centella asiatica."
• Jun Sodium alginate functionalized biocompatible selenium nanocarriers loaded trans-resveratrol for mitochondrial targeted HepG2 hepatocellular carcinoma inhibition study. (Nanomedicine (London, England), 2026, PMID 42165412): "To investigate the use of sodium alginate (SA) for functionalization of selenium nanoparticles (SA@Se NPs) in developing biocompatible nanocarrier to enhance stability, mitochondrial targeting and anticancer efficacy of trans-resveratrol (TRV)."
• Jun Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Profiling, Antioxidant, Antibacterial, and Antidiabetic Properties of Fagonia cretica L.: Insights From In Vitro and In Silico Approaches. (ChemistryOpen, 2026, PMID 42168772): "The phytochemical profile, established by LC-ESI-MS/MS, revealed a predominance of phenolic acids (salicylic, ferulic, sinapic, gallic), flavonoids (quercetin, luteolin, apigenin, catechin, epicatechin), and the stilbene resveratrol."
• Jun Synergistic Chemoimmunotherapy of Hepatocellular Carcinoma via ROS-Responsive Carrier-Free Prodrug Nanoparticles. (Nano letters, 2026, PMID 42159189): "The oxalate ester linkage enabled selective cleavage in the ROS-enriched tumor microenvironment, ensuring precise co-release of Res and OCA."