antioxidant

Overview

An antioxidant is a substance or system that slows, prevents, or counteracts oxidation, particularly the formation and propagation of reactive oxygen species (ROS) and other free-radical intermediates. In biology and medicine, antioxidants are important because excessive oxidative stress can damage lipids, proteins, and nucleic acids and contribute to inflammation, tissue injury, aging, metabolic dysfunction, neurodegeneration, and impaired wound repair. Antioxidants may act by directly scavenging radicals, chelating redox-active metals, interrupting lipid peroxidation chains, or supporting endogenous defense systems such as superoxide dismutase and glutathione-dependent pathways.

In recent biomedical research, antioxidants are frequently studied as components of complex therapeutic strategies rather than as stand-alone agents. They appear in investigations of inflammatory disease, metabolic syndrome, liver injury, skin repair, fertility, encephalitis, and mitochondrial dysfunction, often alongside compounds such as rutin, melatonin, coenzyme Q10, resveratrol, quercetin, and polyphenols. Their effects are commonly interpreted in relation to pathways including MAPK, PI3K/AKT/mTOR, FOXO1, nuclear factor kappa B, and mitochondrial quality-control mechanisms such as mitophagy.

Focus of Latest Publications

Recent publications portray antioxidants as a broad functional class with applications across pharmacology, drug delivery, food science, and plant biology.

Several studies focused on natural products with antioxidant activity. Aconitum septentrionale Koelle extract was described as having antioxidant properties in the context of chronic obstructive pulmonary disease in mice, where it was investigated for its ability to alleviate cigarette smoke- and lipopolysaccharide-induced disease through modulation of the MAPK pathway. Similarly, rutin was examined in atopic dermatitis research and described as a flavonoid with documented antioxidant, cytoprotective, and anti-inflammatory properties. Triphala, an Ayurvedic formulation containing Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica, was also reported to have anti-inflammatory and antioxidant properties in periodontitis models. Other plant-derived sources included Costus pictus leaf extract, Cucurbita maxima leaf aqueous extract, Gastrodia elata, dandelion (Taraxacum officinale), and Wumei Wan components, all discussed in relation to antioxidant activity or antioxidant-associated pharmacology.

A second group of studies examined antioxidants in metabolic, hepatic, and cardiovascular disease. Calcitriol and candesartan were reported to mitigate monosodium glutamate-exacerbated metabolic syndrome and MASLD/MASH in rats, with the authors noting antioxidant, anti-inflammatory, and antifibrotic effects alongside downregulation of mGLuR5, ketohexokinase, and FOXO1. In another study, urolithin A was reported to alleviate vascular remodeling in hypertensive rats through mitochondrial SIRT3-mediated SOD2 deacetylation and antioxidation. Related work on diabetic kidney disease highlighted mitochondria-targeted drugs, including antioxidants, as emerging therapeutic opportunities, and a broader review of ovarian aging and longevity discussed antioxidants among interventions aimed at modulating aging-related pathways.

Antioxidants were also central to regenerative medicine and wound healing. A propolis, tea tree oil, and jojoba oil nanoemulgel was developed with enhanced antioxidant, anti-inflammatory, and wound-healing activities. Another study described hierarchically engineered injectable hydrogels loaded with polyphenol, reporting synergistic antioxidant, anti-inflammatory, and antibacterial properties. A multifunctional bioactive peptide-laden, adhesion-switchable dual-crosslinked hydrogel was shown in vivo to support burn wound healing through hemostasis, antibacterial activity, antioxidant effects, anti-inflammation, angiogenesis, and tissue regeneration. These studies collectively suggest that antioxidant activity is often leveraged to reduce oxidative injury while supporting tissue repair.

A major theme in the recent literature is delivery and stabilization of antioxidants. One study developed a 3D-printed hollow microneedle platform for intradermal delivery of antioxidant-loaded nanocarriers, explicitly addressing the poor penetration of topical antioxidants through the stratum corneum and the need to protect labile compounds. Another study used nanoencapsulation of anise oil to improve antimicrobial and antioxidant effects for food preservation. A separate report on nanobubbles suppressing singlet oxygen-mediated oxidation noted that antioxidants are traditionally used to relieve oxidative stress but are limited by poor stability in vivo and inadequate tissue targeting. These studies emphasize that formulation science is increasingly important for translating antioxidant activity into practical use.

Antioxidants were also studied in reproductive medicine and nutraceutical contexts. A retrospective cohort study in women with PCOS evaluated a 3.6:1 myo-inositol to D-chiro-inositol ratio supplement enriched with antioxidants before IVF-ICSI, aiming to improve fertility outcomes. The study framed antioxidants as part of a preconception intervention rather than as isolated agents. In a related vein, melatonin and coenzyme Q10 were investigated for their antioxidant intervention effects in human adipose-derived mesenchymal stem cells, with the work linking antioxidant treatment to restoration of mitophagy and mitochondrial proteostasis.

Several publications addressed mechanistic and cellular antioxidant biology. A nanozyme-based antioxidant platform was designed for targeted scavenging of ROS and alleviating encephalitis, with the stated aim of improving drug delivery across the blood-brain barrier. Another study on mitochondrial quality control in diabetic kidney disease placed antioxidants within a broader therapeutic landscape involving mitochondrial protection. In plant biology, arbuscular mycorrhizal fungi were reported to boost enzymatic antioxidants in Lactuca sativa infected with Alternaria alternata, illustrating the role of antioxidant defenses in stress resistance. In fermentation research, supplementation with hemin and antioxidants reduced oxidative stress caused by high dissolved oxygen and improved nisin production by Lactococcus lactis CF6.

Across these studies, antioxidants were repeatedly linked to oxidative stress, ROS, lipid oxidation, inflammation, fibrosis, and mitochondrial dysfunction. Related entities such as glutathione, hydrogen peroxide, superoxide dismutase, reactive oxygen species, and Intracellular ROS were frequently implicated in the underlying biology. The publications collectively reinforce the view that antioxidant research spans both endogenous defense systems and exogenous compounds, with applications ranging from disease modification to formulation engineering and food preservation.

Key Publications

• Mar Aconitum septentrionale Koelle extract alleviates cigarette smoke and lipopolysaccharide-induced chronic obstructive pulmonary disease in mice by modulating the MAPK pathway. (Journal of ethnopharmacology, 2026, PMID 41864552): "Aconitum septentrionale Koelle (ASK) exhibits multiple pharmacological properties, including anti-inflammatory, antitumor, and antioxidant activities, and is commonly used in Mongolian medicine to treat respiratory disorders."
• Jun Calcitriol and candesartan mitigate monosodium glutamate-exacerbated metabolic syndrome and MASLD/MASH in rats: modulation of GLuR5/Ketohexokinase/FoxO1 axis. (Naunyn-Schmiedeberg's archives of pharmacology, 2026, PMID 42362764): "Both drugs mitigated most of the FF/MSG-induced metabolic and hepatic manifestations by downregulating mGLuR5, hetohexokinase, and FoxO1, beside their antioxidant, antiinflammatory, and antifibrotic effects."
• May Preclinical development of a 3D-printed hollow microneedle platform for intradermal delivery of antioxidant-loaded nanocarriers. (International journal of pharmaceutics, 2026, PMID 42140402): "The poor penetration of topical antioxidants underscores the need for advanced intradermal delivery platforms that overcome stratum corneum limitations while protecting labile compounds."
• Jun Nanobubbles Suppressing Singlet Oxygen-Mediated Oxidation via Size-Dependent Interfacial Effects. (Langmuir : the ACS journal of surfaces and colloids, 2026, PMID 42262866): "Traditionally, antioxidants are suggested to relieve oxidative stress in the body; however, their efficacy is limited by poor stability in vivo and inadequate tissue targeting in clinical practice."
• Jun A 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based food supplement before IVF improves fertility in women with PCOS: a pilot observational retrospective cohort study. (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2026, PMID 42334964): "This study aimed to evaluate whether taking a 3.6:1 MYO:DCI inositol-based supplement enriched with antioxidants for at least 1 month prior to controlled ovarian stimulation could improve IVF-ICSI outcomes."
• Jun Rutin targets PD-L1 for the treatment of atopic dermatitis: network pharmacological analysis and experimental evidence. (International immunopharmacology, 2026, PMID 41931959): "Rutin, a bioactive flavonoid abundant in traditional medicinal plants, has documented ethnomedical uses in inflammatory conditions and exhibits antioxidant, cytoprotective, and anti-inflammatory properties."
• Jun A comprehensive insight into optimized ultrasound-assisted extraction of bioactive compounds and antioxidant activities from dandelion (Taraxacum officinale) plant extract using response surface methodology. (Ultrasonics sonochemistry, 2026, PMID 42068787): "Concludively, results of present study give a comprehensive insight into optimized ultrasound-assisted extraction method for recovery of maximum antioxidants and bioactive compounds from dandelion using a combination of BBD and RSM."
• May Integrative Analysis of Triphala's Therapeutic Mechanisms in Periodontitis: Network Pharmacology-guided Investigation with Experimental Validation in Cellular and Animal Models. (Oral health & preventive dentistry, 2026, PMID 42205105): "Triphala (TRP), a traditional Ayurvedic formulation comprising equal proportions of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica, has demonstrated anti-inflammatory and antioxidant properties."
• May Targeted Scavenging of Reactive Oxygen Species and Alleviating Encephalitis Using Nanozyme-Based Antioxidant Platform. (ACS applied materials & interfaces, 2026, PMID 42138488): "This multifunctional nanoplatform, which integrates targeted delivery, fluorescence imaging, antioxidant, and immune regulation, is expected to improve the problem that drugs are difficult to effectively cross the BBB in the treatment of encephalitis."
• May Development and evaluation of a propolis, tea tree oil, and jojoba oil nanoemulgel with enhanced antioxidant, anti-inflammatory, and wound-healing activities. (Scientific reports, 2026, PMID 42185365): "The developed green formula, resulting from both the low-energy, environmentally friendly preparation method and the natural origin of its constituents, was demonstrated to be an antioxidant and inflammatory and to accelerate wound healing, suggesting it could be used as a natural formula for topical wound healing application."